Water → HCID 5100758, compound

HRID 2371704Notes

Reaction equation

HRID 2371704 reaction equation
[CH2:1]([N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[S:6][C:5]1=[NH:13])[CH:2]=[CH2:3].C(N(CC)CC)C.[C:21](Cl)(=[O:26])[C:22]([CH3:25])([CH3:24])[CH3:23].O>O1CCCC1>[CH2:1]([N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[S:6][C:5]1=[N:13][C:21](=[O:26])[C:22]([CH3:25])([CH3:24])[CH3:23])[CH:2]=[CH2:3]

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 62493Pivaloyl chlorideHCID 14823531HCID 14823531, compound

Product 1

HCID 5100758HCID 5100758, compoundYield 90.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 2.0 g of 3-allyl-2-iminobenzothiazole and 1.5 g of triethylamine in 30 ml of tetrahydrofuran was added 1.3 g of pivaloyl chloride dropwise at room temperature under stirring. After reacting for five hours, the reaction mixture was poured into approximately 200 ml of water. The crystals precipitated were collected by filtering to thereby obtain 2.6 g of the objective compound.

Workup

  1. customThe crystals precipitated
  2. customwere collected
  3. filtrationby filtering

Sources & evidence

ORD record
ord-30e00036d4194ac6a9aa43619b106fa3
Source dataset
uspto-grants-1992_03
Patent number
US05095025

Reaction notes

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