Methylamine → HCID 15042207, compound

HRID 2371732Notes

Reaction equation

HRID 2371732 reaction equation
[Cl:1][C:2]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9](Cl)=[O:10])[CH2:6]1.[CH3:20][NH2:21]>O1CCCC1.O>[Cl:1][C:2]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9]([NH:21][CH3:20])=[O:10])[CH2:6]1

Participants

5

Reactant 2

HCID 6329MethylamineHCID 15042205HCID 15042205, compound

Product 1

HCID 15042207HCID 15042207, compoundYield 109.6%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 2 g (0.0065 mole) of 3-[2-chloro-4-(trifluoromethyl)phenoxy]-1-azetidinecarbonyl chloride in 15 ml of tetrahydrofuran was treated while stirring with 1 ml (0.013 mole) of 40% aqueous monomethylamine. After stirring for 16 h the reaction mixture was diluted with 100 ml of water and the solid which precipitated was collected by filtration (2.4 g). Recrystallization from benzene/ligroin yielded 2.2 g of white crystals, mp 160°-161°.

Workup

  1. customthe solid which precipitated
  2. filtrationwas collected by filtration (2.4 g)
  3. customRecrystallization from benzene/ligroin

Sources & evidence

ORD record
ord-967912cdcdd24748ba3078d8ac61cf2e
Source dataset
uspto-grants-1992_03
Patent number
US05095014

Reaction notes

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