Methylamine → HCID 15042209, compound

HRID 2371738Notes

Reaction equation

HRID 2371738 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9](Cl)=[O:10])[CH2:6]1.[CH3:16][NH2:17]>O1CCCC1.O>[Cl:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9]([NH:17][CH3:16])=[O:10])[CH2:6]1

Participants

5

Reactant 2

HCID 6329MethylamineHCID 15042228HCID 15042228, compound

Product 1

HCID 15042209HCID 15042209, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A stirred solution of 4.5 g (0.018 mol) of 3-(2-chlorophenoxy)-1-azetidinecarbonyl chloride in 20 ml of tetrahydrofuran was treated with 4 ml (0.05 mol) of 40% aqueous monomethylamine and stirred for 16 h. The reaction mixture was diluted with 200 ml of water and the precipitated product collected by filtration (4.3 g). The crude product was recrystallized from benzene/ligroin yielding 3.9 g (90.0%) of fine white crystals, mp 129.5°-131.5° C.

Workup

  1. filtrationthe precipitated product collected by filtration (4.3 g)
  2. customThe crude product was recrystallized from benzene/ligroin yielding 3.9 g (90.0%) of fine white crystals, mp 129.5°-131.5° C.

Sources & evidence

ORD record
ord-e0cb67827f964a2a95388a10e18716c9
Source dataset
uspto-grants-1992_03
Patent number
US05095014

Reaction notes

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