Ammonium Hydroxide → HCID 15042212, compound

HRID 2371741Notes

Reaction equation

HRID 2371741 reaction equation
[Cl:1][C:2]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9](Cl)=[O:10])[CH2:6]1.[OH-].[NH4+:18]>O1CCCC1.O>[Cl:1][C:2]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9]([NH2:18])=[O:10])[CH2:6]1

Participants

5

Reactant 2

HCID 14923Ammonium HydroxideHCID 199062193-(2,4-Dichlorophenoxy)-1-azetidinecarbonyl chloride

Product 1

HCID 15042212HCID 15042212, compoundYield 87.9%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A stirred solution of 4.8 g (0.017 mole) of 3-(2,4-dichlorophenoxy)-1-azetidinecarbonyl chloride in 20 mL of tetrahydrofuran was treated with 3.0 mL (0.05 mole) of 57% ammonium hydroxide. After stirring for 5 h, the reaction mixture was diluted with 200 mL of water and the precipitated solid collected by filtration (4.1 g). The crude product was recrystallized from acetonitrile/water to yield 3.9 g (87.9%) of white crystals, mp 169°-170° C.

Workup

  1. filtrationthe precipitated solid collected by filtration (4.1 g)
  2. customThe crude product was recrystallized from acetonitrile/water

Sources & evidence

ORD record
ord-8a451f886de543d88136bbef2c1cdb22
Source dataset
uspto-grants-1992_03
Patent number
US05095014

Reaction notes

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