Sodium Hydroxide → HCID 24837049, compound

HRID 2371773Notes

Reaction equation

HRID 2371773 reaction equation
[OH-].[Na+].C[O:4][C:5](=O)[CH2:6][N:7]([C:14]([C@H:16]1[CH2:21][CH2:20][CH2:19][CH2:18][C@H:17]1[C:22]([OH:24])=[O:23])=[O:15])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.C1(NCC(OC)=O)C=CC=CC=1.Cl.NO>CO>[O:4]=[CH:5][CH2:6][N:7]([C:14]([C@H:16]1[CH2:21][CH2:20][CH2:19][CH2:18][C@H:17]1[C:22]([OH:24])=[O:23])=[O:15])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

6

Reactant 4

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 571509Methyl 2-(phenylamino)acetateHCID 54141615HCID 54141615, compound

Product 1

HCID 24837049HCID 24837049, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
15 °C

Procedure

A solution of 1.32 g (33 mmoles) of NaOH in 32 ml of methanol, is added under stirring at a temperature of 10° C., with 3.19 g (10 mmoles), of cis-2-[[N-[2-methoxy-2-oxoethyl]-N-phenylamino]carbonyl]-cyclohexanecarbo xylic acid (prepared from the anhydride of the cis-1,2-cychlohexanbicarboxylic acid and methyl N-phenyl-aminoacetate according to a process like that disclosed in the example 2), and then with 0.764 g (11 mmoles) of hydroxylamine hydrochloride. The resulting suspension is maintained under stirring at 15° C. for 6 hours, then at rest for the night.

Workup

  1. temperatureThe resulting suspension is maintained

Sources & evidence

ORD record
ord-68c16683e5ad4654ad5dd0d7a2582076
Source dataset
uspto-grants-1992_03
Patent number
US05095137

Reaction notes

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