反应详情

1.0 g (3.8 mmol) of (1-cyanocyclohexyl)acetic acid benzyl ester was distilled in 20 ml of methanol, mixed with 0.2 g of Rh/C 5 percent and hydrogenated at 10 bars of hydrogen pressure. After 23 hours at room temperature the suspension was filtered, the filtrate was concentrated to 3 ml, mixed with 25 ml of ethanol, concentrated to 4 ml and put on the cooling shelf. The precipitated product was filtered, washed with ethanol and dried. 0.18 g of Gabapentin was obtained, corresponding to a yield of 27 percent (relative to the (1-cyanocyclohexyl)acetic acid benzyl ester used). Data for the product was:

1. filtrationAfter 23 hours at room temperature the suspension was filtered
2. concentrationthe filtrate was concentrated to 3 ml
3. additionmixed with 25 ml of ethanol
4. concentrationconcentrated to 4 ml
5. filtrationThe precipitated product was filtered
6. washwashed with ethanol
7. customdried