反应详情

To a solution of 3.12 g (E)-3-[4-(2,5-dimethyl-1-H-pyrrol-1-yl)phenyl]-N-acetoxy-N-methyl-2-propenamide in 2-propanol (50 ml) cooled to 0°, 1N aqueous lithium hydroxide (13 ml) is added with stirring. The mixture is stirred at room temperature for 30 minutes, then partitioned between ethyl acetate and 2N HCl. The organic phase is washed with brine, dried over magnesium sulphate and concentrated to dryness. Recrystallization from ethyl acetate yields (E)-3-[4-(2,5-dimethyl-1-H-pyrrol-1-yl)-phenyl]-N-hydroxy-N-methyl-2-propenamide of Example 1.

1. stirringThe mixture is stirred at room temperature for 30 minutes
2. custompartitioned between ethyl acetate and 2N HCl
3. washThe organic phase is washed with brine
4. dry with materialdried over magnesium sulphate
5. concentrationconcentrated to dryness
6. customRecrystallization from ethyl acetate