反应详情

温度

0 °C

Methyl 2,3,5-tri-O-benzyl-L-xylofuranoside (22.7 g, 56.30 mmol) is dissolved at 0° C. in a 9:1 mixture of trifluoroacetic acid and water (200 mL) and stirred at 0° C. overnight. The mixture is put to dryness under reduced pressure. The oily residue is dissolved in ethyl acetate and washed three times with a saturated solution of sodium bicarbonate. The organic layer is dried over sodium sulfate, filtered and put to dryness under reduced pressure to afford an oil. Flash chromatography on silica gel and elution with a 7:3 mixture of cyclohexane and ethyl acetate yield methyl 2,3,5-tri-O-benzyl-L-xylofuranose as an oil (11.7 g, 53%).

1. washwashed three times with a saturated solution of sodium bicarbonate
2. dry with materialThe organic layer is dried over sodium sulfate
3. filtrationfiltered
4. customto afford an oil
5. washFlash chromatography on silica gel and elution
6. additionwith a 7:3 mixture of cyclohexane and ethyl acetate