Hydrochloric Acid → HCID 19902820, compound

HRID 2372192Notes

Reaction equation

HRID 2372192 reaction equation
[Li].[C:2]([C:5]1[C:6]([C:12]([OH:14])=[O:13])=[N:7][C:8](Cl)=[N:9][CH:10]=1)(=[O:4])[CH3:3].C(=O)(O)[O-].[Na+].Cl>O.[Pd]>[C:2]([C:5]1[C:6]([C:12]([OH:14])=[O:13])=[N:7][CH:8]=[N:9][CH:10]=1)(=[O:4])[CH3:3]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 3028194LithiumHCID 19902810HCID 19902810, compound

Product 1

HCID 19902820HCID 19902820, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

To a mixture of the lithium salt of 5-acetyl-2-chloro-4-pyrimidinecarboxylic acid (1.1 g, 4.90 mmol) and sodium bicarbonate (0.5 g, 5.95 mmol) in 20 ml of water is added 10% palladium on carbon (0.1 g), and the reaction mixture is kept under H2 overnight. It is then acidified with 1M hydrochloric acid (6 ml) and concentrated. The resulting solid is filtered, rinsed with water and dried to give 5-acetyl-4-pyrimidinecarboxylic acid.

Workup

  1. concentrationconcentrated
  2. filtrationThe resulting solid is filtered
  3. washrinsed with water
  4. customdried

Sources & evidence

ORD record
ord-3e99b2da956a467aa891f3a119a7107f
Source dataset
uspto-grants-1992_03
Patent number
US05098462

Reaction notes

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