Hydrochloric Acid → 5-Ethyl-2,3-pyridinedicarboxylic acid

HRID 2372219Notes

Reaction equation

HRID 2372219 reaction equation
CN(C)[N:3]1[CH:8]=[C:7]([CH2:9][CH3:10])[CH2:6][C:5]2[C:11]([O:13][C:14](=[O:15])[C:4]1=2)=[O:12].Cl.C1C[O:21]CC1>>[CH2:9]([C:7]1[CH:6]=[C:5]([C:11]([OH:21])=[O:12])[C:4]([C:14]([OH:13])=[O:15])=[N:3][CH:8]=1)[CH3:10]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 54286994HCID 54286994, compound

Product 1

HCID 1136065-Ethyl-2,3-pyridinedicarboxylic acid

Procedure

The above anhydride is dissolved in THF, and 100 ml of 2M HCl is added. The mixture is stirred and the THF is distilled off. The residue is recrystallized from THF to give 5-ethyl-2,3-pyridinedicarboxylic acid.

Workup

  1. distillationthe THF is distilled off
  2. customThe residue is recrystallized from THF

Sources & evidence

ORD record
ord-e7f1732581714f3eabe9983f3a81c692
Source dataset
uspto-grants-1992_03
Patent number
US05098466

Reaction notes

Loading…