Hydrazine hydrate (1:1) → 3-Amino-1-(3,5-difluorophenyl)urea

HRID 2372234Notes

Reaction equation

HRID 2372234 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:9][C:10](=[O:18])OC2C=CC=CC=2)[CH:5]=[C:6]([F:8])[CH:7]=1.O.[NH2:20][NH2:21]>>[F:1][C:2]1[CH:3]=[C:4]([NH:9][C:10](=[O:18])[NH:20][NH2:21])[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 22927143O-phenyl 3,5-difluorophenylcarbamate

Product 1

HCID 152786873-Amino-1-(3,5-difluorophenyl)urea

Procedure

To a solid 100 mg of O-phenyl 3,5-difluorophenylcarbamate 0.7 mL of hydrazine monohydrate was added. After stirring for 3 h at room temperature a white solid is collected by filtration, washed with water and ether. Removal of traces of the solvents in vacuo gives 4-(3,5-difluorophenyl)-semicarbazide: m.p. 177°-179° C.

Workup

  1. filtrationis collected by filtration
  2. washwashed with water and ether
  3. customRemoval of traces of the solvents in vacuo

Sources & evidence

ORD record
ord-1c2a9e154d884b018656e8f52aecdcc5
Source dataset
uspto-grants-1992_03
Patent number
US05098466

Reaction notes

Loading…