Isobutanol → HCID 19902865, compound

HRID 2372236Notes

Reaction equation

HRID 2372236 reaction equation
C[O:2][C:3]([NH:5][C:6]1[CH:11]=[C:10]([F:12])[CH:9]=[C:8]([Cl:13])[CH:7]=1)=O.O.[NH2:15][NH2:16].C(O)C(C)C>O>[Cl:13][C:8]1[CH:7]=[C:6]([NH:5][C:3](=[O:2])[NH:15][NH2:16])[CH:11]=[C:10]([F:12])[CH:9]=1

Participants

5

Reactant 3

HCID 6560IsobutanolHCID 24654Hydrazine hydrate (1:1)HCID 19902866HCID 19902866, compound

Product 1

HCID 19902865HCID 19902865, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

N-methoxycarbonyl-3-chloro-5-fluoroaniline (51.8 gms, 254M) is added to a mixture of hydrazine hydrate (125 ml) and isobutyl alcohol (160 ml). The mixture is heated to 100° for 10 hours under nitrogen. The solution is cooled to room temperature, diluted with water and filtered. The solid is rinsed with water (2×) and dried under vacuum to give 4-(3-chloro-5-fluorophenyl)semicarbazide as a white solid.

Workup

  1. temperatureThe mixture is heated to 100° for 10 hours under nitrogen
  2. filtrationfiltered
  3. washThe solid is rinsed with water (2×)
  4. customdried under vacuum

Sources & evidence

ORD record
ord-2a82398df801480d83d4163e7302957c
Source dataset
uspto-grants-1992_03
Patent number
US05098466

Reaction notes

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