反应详情

After 46.4 g of concentrated sulfuric acid and 21.2 g (147 mmol) of (-)-2-methyloctanol were added to 330 ml of water, 63.4 g (401 mmol) of potassium permanganate was added dropwise over 7.3 hours while holding a reaction temperature at 21°-28° C. The thus obtained reaction mixture was poured into 270 ml of ice water, and 52 g of sodium bisulfite was added thereto. After pH was adjusted to not more than 1 with hydrochloric acid, the resulting product was extracted with ether and further with a 10% aqueous solution of sodium hydroxide. The extract was added with hydrochloric acid to adjust pH to not more than 1 and again extracted with chloroform. The thus obtained extract was washed with water, dried, concentrated and then distilled under a reduced pressure (0.28 mmHg, 91°-94° C.) to obtain 15.3 g (yield: 64%) of (+)-2-methyl octanoic acid.

1. additionwas added dropwise over 7.3 hours
2. customat 21°-28° C
3. customThe thus obtained reaction mixture
4. additionwas added
5. extractionthe resulting product was extracted with ether and further with a 10% aqueous solution of sodium hydroxide
6. additionThe extract was added with hydrochloric acid
7. extractionagain extracted with chloroform
8. customThe thus obtained
9. extractionextract
10. washwas washed with water
11. customdried
12. concentrationconcentrated
13. distillationdistilled under a reduced pressure (0.28 mmHg, 91°-94° C.)