反应详情

温度

60 °C

A mixture of N-(4-fluorobenzyl)-2-(chloromethyl)-3,4-dimethyl-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide (216 mg, 0.570 mmol), (1R)-2-(methylamino)-1-pyrimidin-2-ylethanol dihydrochloride (Preparation 104, 155 mg, 0.686 mmol) and diisopropylethylamine (600 μL, 3.44 mmol) in dry DMF (10.0 mL) was stirred at 60° C. for 20 hours. The solution was then diluted with water (75 mL). The resulting precipitate was collected by filtration and the collected solid was dried at 60° C. in vacuo, providing 209 mg of a tan solid.

1. filtrationThe resulting precipitate was collected by filtration
2. customthe collected solid was dried at 60° C. in vacuo