N,N-Diethylaniline → HCID 19903228, compound

HRID 2372321Notes

Reaction equation

HRID 2372321 reaction equation
[CH2:1]([O:8][C:9]1[C:10](O)=[N:11][C:12]([C:15]([F:18])([F:17])[F:16])=[N:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)C1C=CC=CC=1)C.P(Cl)(Cl)([Cl:33])=O>>[CH2:1]([O:8][C:9]1[C:10]([Cl:33])=[N:11][C:12]([C:15]([F:18])([F:17])[F:16])=[N:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 7061N,N-DiethylanilineHCID 24813Phosphorus oxychlorideHCID 178517790HCID 178517790, compound

Product 1

HCID 19903228HCID 19903228, compoundYield 42.6%

Conditions

Temperature
100 °C

Procedure

A mixture of XXIII (3.3 g, 12.2 mmol), diethyl aniline (1.94 mL, 12.2 mmol), and phosphorus oxychloride (0.758 mL, 8.13 mmol) was heated in a 100° C. oil bath for 3 hr. The dark reaction mixture was vacuum distilled to give the product as a clear oil (1.0 g, 28.4%).

Workup

  1. customThe dark reaction mixture
  2. distillationdistilled

Sources & evidence

ORD record
ord-d0c6ab7df7324d4ea208f7efc727ca72
Source dataset
uspto-grants-1992_03
Patent number
US05098904

Reaction notes

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