Morpholine → HCID 19902175, compound

HRID 2372722Notes

Reaction equation

HRID 2372722 reaction equation
[CH:1]1([C:4]2[N:8]=[C:7]([C:9]3[N:10]=[CH:11][N:12]4[C:21]5[CH:20]=[CH:19][CH:18]=[C:17](F)[C:16]=5[C:15]5=[N:23][CH2:24][CH2:25][N:14]5[C:13]=34)[O:6][N:5]=2)[CH2:3][CH2:2]1.[NH:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>CN(C=O)C>[CH:1]1([C:4]2[N:8]=[C:7]([C:9]3[N:10]=[CH:11][N:12]4[C:21]5[CH:20]=[CH:19][CH:18]=[C:17]([N:26]6[CH2:31][CH2:30][O:29][CH2:28][CH2:27]6)[C:16]=5[C:15]5=[N:23][CH2:24][CH2:25][N:14]5[C:13]=34)[O:6][N:5]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 19902147HCID 19902147, compound

Product 1

HCID 19902175HCID 19902175, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
120 °C

Procedure

A solution of 5-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-12-fluoro-2,3-dihydrodiimidazo[1,5-a:1',2'-c]quinazoline (0.25 g, 0.7 mmol) in a mixture of morpholine (10 ml) and DMF (15 ml) was heated at 120° C. for 6 h. Then the solvent was evaporated and the solid residue was triturated with 10 ml of water, filtered off and dried to give the title compound as pale crystals, m.p. 217°-220° C. Yield 0.16 g (57%). (Compound 46).

Workup

  1. customThen the solvent was evaporated
  2. customthe solid residue was triturated with 10 ml of water
  3. filtrationfiltered off
  4. customdried

Sources & evidence

ORD record
ord-f54706184d0a4a68852a3d606e660115
Source dataset
uspto-grants-1992_03
Patent number
US05100895

Reaction notes

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