Hydrochloric Acid → HCID 21200841, compound

HRID 2372816Notes

Reaction equation

HRID 2372816 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=2)(=[O:11])=[O:10])=[CH:5][CH:4]=1.Cl.[NH+]1C=CC=CC=1.Cl>>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([S:9]([C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=2)(=[O:11])=[O:10])=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 19902347HCID 19902347, compoundHCID 21584435Pyridinium hydrochloride

Product 1

HCID 21200841HCID 21200841, compoundYield 99%

Procedure

A mixture of 5.12 g (0.0187 mol) of 4-[(4-methoxyphenyl)sulfonyl]benzonitrile and 21.6 g of pyridinium hydrochloride is kept at 200° C. for 2 hours. After cooling, the reaction medium is hydrolyzed in a 1 N solution of hydrochloric acid. The precipitate formed is filtered off and rinsed with a 1 N solution of hydrochloric acid and then with water until the pH of the washings is neutral. 4.5 g (yield: 99%) of the expected product are thus obtained in the form of a gray solid.

Workup

  1. temperatureAfter cooling
  2. customThe precipitate formed
  3. filtrationis filtered off
  4. washrinsed with a 1 N solution of hydrochloric acid

Sources & evidence

ORD record
ord-a6a510a589844a44913fc4d911258c76
Source dataset
uspto-grants-1992_03
Patent number
US05100913

Reaction notes

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