Phosphorus oxychloride → 2-n-Butyl-4-chloro-5-ethyl-6-methylpyrimidine

HRID 2372851Notes

Reaction equation

HRID 2372851 reaction equation
[CH2:1]([C:5]1[NH:10][C:9](=O)[C:8]([CH2:12][CH3:13])=[C:7]([CH3:14])[N:6]=1)[CH2:2][CH2:3][CH3:4].P(Cl)(Cl)([Cl:17])=O>>[CH2:1]([C:5]1[N:10]=[C:9]([Cl:17])[C:8]([CH2:12][CH3:13])=[C:7]([CH3:14])[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 1356254552-n-Butyl-5-ethyl-6-methylpyrimidin-4(3H)-one

Product 1

HCID 199022332-n-Butyl-4-chloro-5-ethyl-6-methylpyrimidine

Procedure

The pyrimidinone from Example 1 2-butyl-5-ethyl-6-methylpyrimidin-4(3H)-one is converted to the title compound upon treatment with phosphoryl chloride as described by Gabriel and Colman (Ber. 1899, 32, 2921) and by Marshall and Walker (J. Chem. Soc., 1951, 1004).

Sources & evidence

ORD record
ord-7fd8798c909940fa954a3d676f720547
Source dataset
uspto-grants-1992_03
Patent number
US05100897

Reaction notes

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