Phosphorus oxychloride → 2-n-Butyl-4-chloro-5,6-dimethylpyrimidine

HRID 2372853Notes

Reaction equation

HRID 2372853 reaction equation
[CH2:1]([C:5]1[NH:10][C:9](=O)[C:8]([CH3:12])=[C:7]([CH3:13])[N:6]=1)[CH2:2][CH2:3][CH3:4].P(Cl)(Cl)([Cl:16])=O>>[CH2:1]([C:5]1[N:10]=[C:9]([Cl:16])[C:8]([CH3:12])=[C:7]([CH3:13])[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 1356254542-n-Butyl-5,6-dimethylpyrimidin-4(3H)-one

Product 1

HCID 199022302-n-Butyl-4-chloro-5,6-dimethylpyrimidine

Procedure

The pyrimidine from Example 2 2-n-butyl-5,6-dimethylpyrimidin-4(3H)-one is converted to the title compound upon treatment with phosphoryl chloride as described by Gabriel and Colman (Ber. 1899, 32, 2921) and by Marshall and Walker (J. Chem. Soc., 1951, 1004).

Sources & evidence

ORD record
ord-0c1ba5391b0e4101b903f99227f3be8c
Source dataset
uspto-grants-1992_03
Patent number
US05100897

Reaction notes

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