Benzylamine → HCID 11483844, compound

HRID 237372Notes

Reaction equation

HRID 237372 reaction equation
[CH3:1][O:2][C:3]([C:5]1[S:15][C:8]2[N:9]=[C:10]([NH2:14])[N:11]=[C:12](Cl)[C:7]=2[CH:6]=1)=[O:4].[CH2:16]([NH2:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C1COCC1>[CH3:1][O:2][C:3]([C:5]1[S:15][C:8]2[N:9]=[C:10]([NH2:14])[N:11]=[C:12]([NH:23][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:7]=2[CH:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 11694427HCID 11694427, compound

Product 1

HCID 11483844HCID 11483844, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The 2-amino-4-chloro-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester (100 mg, 0.39 mmol), benzylamine (100 μl) in 4 mL of THF are submitted to MW irradiation at 110° C. for 35 mins. The reaction was cooled to room temperature and worked up (acidic) and purified using standard conditions for a neutral compound.

Workup

  1. custompurified

Sources & evidence

ORD record
ord-9fbcb7ba74424b3aba493cef24ab06c0
Source dataset
uspto-grants-2014_02
Patent number
US08642594B2

Reaction notes

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