Lithium Hydroxide → HCID 59852576, compound

HRID 2373783Notes

Reaction equation

HRID 2373783 reaction equation
C[O:2][C:3](=[O:36])[C@@H:4]([NH:25][C:26](=[O:35])[C:27]1[CH:32]=[C:31]([Br:33])[CH:30]=[CH:29][C:28]=1[OH:34])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[CH:14][CH:13]=2)=[CH:8][CH:7]=1.[Li+].[OH-]>C1COCC1.CO>[Br:33][C:31]1[CH:30]=[CH:29][C:28]([OH:34])=[C:27]([CH:32]=1)[C:26]([NH:25][C@@H:4]([CH2:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)=[CH:14][CH:13]=2)=[CH:10][CH:11]=1)[C:3]([OH:36])=[O:2])=[O:35]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 59852552HCID 59852552, compound

Product 1

HCID 59852576HCID 59852576, compoundYield 104.4%

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

To a solution of the preceding compound, (2S)-(5-Bromo-2-hydroxy-benzoylamino)-3-(4′-phenoxy-biphenyl-4-yl)-propionic acid methyl ester (10 mg, 18 μmol) in THF/MeOH was added aqueous LiOH, as described in General procedure C which, after work-up afforded the title compound, (2S)-(5-Bromo-2-hydroxy-benzoylamino)-3-(4′-phenoxy-biphenyl-4-yl)-propionic acid (10 mg ) LCMS for C28H22BrNO5: 531, 533.

Sources & evidence

ORD record
ord-63e33e334c164a41a7d1763f2b8cd3ed
Source dataset
uspto-grants-2008_12
Patent number
US07459472B2

Reaction notes

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