Triethylamine → HCID 57717668, compound

HRID 2373856Notes

Reaction equation

HRID 2373856 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH:17]([NH2:21])[CH2:18][O:19][CH3:20])=[CH:12][CH:11]=2)[CH:6]=[CH:7][C:8]=1[F:9].[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]2[CH:35]=[CH:34][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:32][CH:31]=2)=[CH:26][C:25]=1[C:40](Cl)=[O:41].C(N(CC)CC)C>>[Cl:2][C:3]1[CH:4]=[C:5]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C@@H:17]([NH:21][C:40]([C:25]3[CH:26]=[C:27]([C:30]4[CH:35]=[CH:34][C:33]([C:36]([F:37])([F:39])[F:38])=[CH:32][CH:31]=4)[CH:28]=[CH:29][C:24]=3[O:23][CH3:22])=[O:41])[CH2:18][O:19][CH3:20])=[CH:12][CH:11]=2)[CH:6]=[CH:7][C:8]=1[F:9]

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 69204842HCID 69204842, compoundHCID 86032170HCID 86032170, compound

Product 1

HCID 57717668HCID 57717668, compoundYield 78.7%

Procedure

4-Methoxy-4′-trifluoromethyl-biphenyl-3-carboxylic acid [2-(3′-chloro-4′-fluoro-biphenyl-4-yl)-1-(R)-methoxymethyl-ethyl]-amide (45 mg) was prepared from 1-(3′-Chloro-4′-fluoro-biphenyl-4-ylmethyl)-2-methoxy-ethylamine hydrochloride salt (35 mg, 0.1 mmol) and 4-Methoxy-4′-trifluoromethyl-biphenyl-3-carbonyl chloride (32 mg, 0.1 mmol) in presence of triethyl amine (41 mg, 0.41 mmol) according to the general procedure M.

Sources & evidence

ORD record
ord-4b35479ed42f4959910fd6be049f603f
Source dataset
uspto-grants-2008_12
Patent number
US07459472B2

Reaction notes

Loading…