反应详情

Hydrochloric acid was added to a solution of 2-Amino-4-(2,4-dichloro-5-(2,2-diethoxyethoxy)-phenyl)-thieno[2,3-d]pyrimidine-6-carboxylic acid ethyl amide in THF and the solution stirred for ˜18 hrs. Dichloromethane was added and the mixture stirred, sodium borohydride was added and the resulting suspension stirred for ˜5 hrs. Dichloromethane was added and the mixture washed with saturated ammonium chloride solution. The solution was dried over anhydrous sodium sulphate and concentrated to a pale yellow solid. The crude product was purified by preparative HPLC, to give the product as an off-white solid.

1. stirringthe mixture stirred
2. stirringthe resulting suspension stirred for ˜5 hrs
3. washthe mixture washed with saturated ammonium chloride solution
4. dry with materialThe solution was dried over anhydrous sodium sulphate
5. concentrationconcentrated to a pale yellow solid
6. customThe crude product was purified by preparative HPLC