Hydrochloric Acid → HCID 86604614, compound

HRID 2373877Notes

Reaction equation

HRID 2373877 reaction equation
[Cl:1][C:2]1[C:3]([CH:8]([NH2:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:4][CH:5]=[CH:6][N:7]=1.Cl>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[C:3]([CH:8]([NH2:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:4][CH:5]=[CH:6][N:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59852815HCID 59852815, compound

Product 1

HCID 86604614HCID 86604614, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of C-(3-chloropyrazin-2-yl)-C-phenylmethylamine (1.582 g, 7.20 mmol) in 1,4-dioxane (≦5 mL), HCl (2 mL, 7.55 mmol, 4M soln. in 1,4-dioxane) was added and left for approx. 5 min. The reaction mixture was filtered and the solid was washed several times with 1,4-dioxane, yielding the title compound as a tan solid. Sample contains ≈0.1 eq. of 1,4-dioxane by 1H NMR; 1H NMR (d-MeOH, 400 MHz) δ 5.85 (s, 1H), 7.35 (s, 1H), 8.44 (d, J=2.4 Hz, 1H), 8.65 (d, J=2.4 Hz, 1H).

Workup

  1. filtrationThe reaction mixture was filtered
  2. washthe solid was washed several times with 1,4-dioxane

Sources & evidence

ORD record
ord-a61692f181bb4b7d9a8d9705f6c1ec90
Source dataset
uspto-grants-2008_12
Patent number
US07459554B2

Reaction notes

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