Water → HCID 178423997, compound

HRID 237389Notes

Reaction equation

HRID 237389 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[C:5]([CH:9]=[O:10])=[C:4]([C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][C:12]=2[CH3:18])[N:3]=1.[S-2:19].[Na+].[Na+].O>CN(C=O)C>[NH2:1][C:2]1[N:3]=[C:4]([C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][C:12]=2[CH3:18])[C:5]([CH:9]=[O:10])=[C:6]([SH:19])[N:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14804Sodium SulfideHCID 595192012-Amino-4-chloro-6-(2,4-dimethyl-phenyl)-pyrimidine-5-carbaldehyde

Product 1

HCID 178423997HCID 178423997, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2-Amino-4-chloro-6-(2,4-dimethylphenyl)-pyrimidine-5-carbaldehyde was added to a suspension of sodium sulphide (5 eq.) in DMF and the mixture stirred for ˜60 mins, to give a yellow suspension. The suspension was poured into water, and the solution filtered. The filtrate was acidified with acetic acid, to give a yellow precipitate. The solids were removed by filtration and washed with water and hexane, dried in vacuo, to give a yellow powder.

Workup

  1. customto give a yellow suspension
  2. filtrationthe solution filtered
  3. customto give a yellow precipitate
  4. customThe solids were removed by filtration
  5. washwashed with water and hexane
  6. customdried in vacuo
  7. customto give a yellow powder

Sources & evidence

ORD record
ord-719820f912b646aea63d62f490ed79d9
Source dataset
uspto-grants-2014_02
Patent number
US08642594B2

Reaction notes

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