Ammonium Chloride → HCID 59853022, compound

HRID 2374005Notes

Reaction equation

HRID 2374005 reaction equation
[C:1]([O:5][C:6](=[O:33])[NH:7][CH2:8][CH:9]1[CH2:12][N:11]([CH2:13][C:14]#[C:15][C:16]2[CH:17]=[N:18][CH:19]=[CH:20][C:21]=2[O:22][C:23]2[CH:28]=[CH:27][C:26]([N+:29]([O-])=O)=[CH:25][C:24]=2[F:32])[CH2:10]1)([CH3:4])([CH3:3])[CH3:2].[NH4+].[Cl-]>[Fe]>[C:1]([O:5][C:6](=[O:33])[NH:7][CH2:8][CH:9]1[CH2:12][N:11]([CH2:13][C:14]#[C:15][C:16]2[CH:17]=[N:18][CH:19]=[CH:20][C:21]=2[O:22][C:23]2[CH:28]=[CH:27][C:26]([NH2:29])=[CH:25][C:24]=2[F:32])[CH2:10]1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 25517Ammonium ChlorideHCID 59853059HCID 59853059, compound

Product 1

HCID 59853022HCID 59853022, compound

Reagents, catalysts & solvents 1

HCID 23925IronCatalyst

Procedure

The title compound was prepared by the reduction of tert-butyl(1-(3-(4-(2-fluoro-4-nitrophenoxy)pyridin-3-yl)prop-2-ynyl)azetidin-3-yl)methylcarbamate (30 mg, 0.66 mmol) in the same manner as in Step E of Example 35 using Fe powder (50 g, 0.091 mmol) and NH4Cl (96 mg, 1.82 mmol). The product was used in subsequent reactions without any purification. MS(ESI+): m/z 371.24 (100), [(M-C4H9)]+; m/z 427.27 (25), (M+H)+.

Workup

  1. customThe product was used in subsequent reactions without any purification

Sources & evidence

ORD record
ord-695cb6bdde5f4f399766d7b9e246feb4
Source dataset
uspto-grants-2008_12
Patent number
US07459562B2

Reaction notes

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