Phthalimide → HCID 23132647, compound

HRID 2374211Notes

Reaction equation

HRID 2374211 reaction equation
O[CH:2]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:3][N:4]1[C:9]2=[N:10][C:11]([C:15]3[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=3)=[CH:12][C:13](=[O:14])[N:8]2[CH2:7][C:6]([CH3:22])([CH3:21])[CH2:5]1.[C:29]1(=[O:39])[NH:33][C:32](=[O:34])[C:31]2=[CH:35][CH:36]=[CH:37][CH:38]=[C:30]12.N(C(OCC)=O)=NC(OCC)=O>O1CCCC1>[CH3:22][C:6]1([CH3:21])[CH2:7][N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]3[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=3)[N:10]=[C:9]2[N:4]([CH2:3][CH:2]([N:33]2[C:29](=[O:39])[C:30]3[C:31](=[CH:35][CH:36]=[CH:37][CH:38]=3)[C:32]2=[O:34])[C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:5]1

Participants

5

Reactant 3

HCID 6809PhthalimideHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 10134136HCID 10134136, compound

Product 1

HCID 23132647HCID 23132647, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 0.2 g (0.531 mmol) of 9-(2-Hydroxy-2-phenyl-ethyl)-7,7-dimethyl-2-(pyridin-4-yl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one, 0.080 g (0.584 mmol) of phthalimide and 0.195 g (0.742 mmol) in 30 ml of anhydrous tetrahydrofuran at 0° C. was added 0.142 ml (0.903 mmol) of diethyl azodicarboxylate and the reaction mixture stirred for 18 h.

Sources & evidence

ORD record
ord-fdc82069f06e406980802847742b1d7e
Source dataset
uspto-grants-2008_12
Patent number
US07462621B2

Reaction notes

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