Water → HCID 135984688, compound

HRID 2374336Notes

Reaction equation

HRID 2374336 reaction equation
Cl[C:2]1[N:3]2[CH:19]=[N:18][N:17]=[C:4]2[C:5]2[N:6]=[CH:7][N:8]([CH:11]3[CH2:16][CH2:15][CH2:14][CH2:13][O:12]3)[C:9]=2[N:10]=1.[OH-:20].[Li+].O>C1COCC1>[O:12]1[CH2:13][CH2:14][CH2:15][CH2:16][CH:11]1[N:8]1[CH:7]=[N:6][C:5]2[C:4]3=[N:17][N:18]=[CH:19][N:3]3[C:2](=[O:20])[NH:10][C:9]1=2

Participants

5

Reactant 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 59853811HCID 59853811, compound

Product 1

HCID 135984688HCID 135984688, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To the solution of 5-chloro-7-(tetrahydro-2H-pyran-2-yl)-7H-[1,2,4]triazolo[3,4-i]purine (0.17 g, 0.50 mmol) in THF (10 mL) was added lithium hydroxide (420 mg, 18 mmol) and water (10 mL). After stirring at room temperature for 10 minutes, the reaction mixture was concentrated under reduced pressure to give the product, which is used for next step without further purification. LCMS calculated for C11H13N6O2 (M+H): 261.1; found: 261.0.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. customto give the product, which
  3. customis used for next step without further purification

Sources & evidence

ORD record
ord-fedb22ef953e423993142acccf2ba866
Source dataset
uspto-grants-2008_12
Patent number
US07462624B2

Reaction notes

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