反应详情

温度

80 °C

To a solution of 4-bromo-3,5-dimethylphenol (1.5 g) and K2CO3 (3.2 g) in N,N-dimethylformamide (12 mL) is added 3-(bromomethyl)tetrahydrofuran (3.6 g). The mixture is stirred for 16 hours at 80° C. and then partitioned between water and ethyl acetate. The organic phase is washed with brine and dried (MgSO4). The solvent is evaporated and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 99:1→70:30) to give the title compound. Yield: 1.72 g; LC (method 1): tR=1.37 min; Mass spectrum (ESI+): m/z=285 [M+H]+.

1. custompartitioned between water and ethyl acetate
2. washThe organic phase is washed with brine
3. dry with materialdried (MgSO4)
4. customThe solvent is evaporated
5. customthe residue is chromatographed on silica gel (cyclohexane/ethyl acetate 99:1→70:30)