1-(2,3-Dihydro-1H-indol-1-yl)ethan-1-one → HCID 21887170, compound

HRID 2374575Notes

Reaction equation

HRID 2374575 reaction equation
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[Cl:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18](Cl)=[O:19]>>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([C:18](=[O:19])[CH2:17][CH2:16][CH2:15][CH2:14][Cl:13])=[CH:10][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 276731-(2,3-Dihydro-1H-indol-1-yl)ethan-1-oneHCID 740895-Chlorovaleryl chloride

Product 1

HCID 21887170HCID 21887170, compoundYield 45.4%

Procedure

Using 1-acetylindoline (1.60 g) and 5-chlorovaleryl chloride (1.70 g) according to the same method as that of Reference Example 1, the title compound (1.26 g) was obtained as colorless crystals having a melting point of 90 to 91° C.

Sources & evidence

ORD record
ord-8bcfd6ca545149bb9c82879e445ab132
Source dataset
uspto-grants-2008_12
Patent number
US07462628B2

Reaction notes

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