Hydrocarbostyril → HCID 21887524, compound

HRID 2374607Notes

Reaction equation

[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]1=[O:11].[Cl:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17](Cl)=[O:18]>>[Cl:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[NH:1][C:2](=[O:11])[CH2:3][CH2:4]2)=[O:18]

Participants

Reactant 2

HCID 64796Hydrocarbostyril

HCID 740895-Chlorovaleryl chloride

Product 1

HCID 21887524HCID 21887524, compound

Procedure

Using 3,4-dihydroquinolin-2(1H)-one (2.94 g) and 5-chloropentanoyl chloride (3.7 g) according to the same method as that of Reference Example 1, the title compound was obtained as colorless crystals (1.59 g) having a melting point of 145 to 146° C.

Sources & evidence

ORD record: ord-3e253b14c3f2441c8a7d7c871b4bc896
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07462628B2

Reaction notes

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