Ethane, 2-bromo-1,1-diethoxy- → HCID 86697134, compound

HRID 237471Notes

Reaction equation

HRID 237471 reaction equation
[Br:1][C:2]1[C:10]([CH3:11])=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][C:3]=1[CH3:12].Br[CH2:14][CH:15](OCC)OCC>C(#N)C>[Br:1][C:2]1[C:3]([CH3:12])=[CH:4][C:5]([C:6]2[O:7][CH:14]=[CH:15][N:8]=2)=[CH:9][C:10]=1[CH3:11]

Participants

4

Reactant 2

HCID 74852Ethane, 2-bromo-1,1-diethoxy-HCID 254178124-Bromo-3,5-dimethylbenzamide

Product 1

HCID 86697134HCID 86697134, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
150 °C

Procedure

In a microwave vial 4-bromo-3,5-dimethylbenzamide (200 mg) is mixed with 2-bromo-1,1-diethoxyethane (1 mL), the vial is sealed and the mixture is heated to 150° C. for 30 minutes. The mixture is diluted with acetonitrile (2 mL) and purified by HPLC on reversed phase to give the title compound. Yield: 125 mg; LC (method 7): tR=1.13 min; Mass spectrum (ESI+): m/z=252 [M+H]+.

Workup

  1. customthe vial is sealed
  2. custompurified by HPLC on reversed phase

Sources & evidence

ORD record
ord-d430168418a146d1be2ed5879f78de14
Source dataset
uspto-grants-2014_02
Patent number
US08642585B2

Reaction notes

Loading…