HCID 24885501, compound → (R)-3-(Carbamoylmethyl)-5-methylhexanoic acid

HRID 2374724Notes

Reaction equation

HRID 2374724 reaction equation
[C:1]([CH2:4][C@@H:5]([CH2:11][CH:12]([CH3:14])[CH3:13])[CH2:6][C:7]([O:9]C)=[O:8])(=[O:3])[NH2:2]>Cl>[C:1]([CH2:4][C@@H:5]([CH2:11][CH:12]([CH3:14])[CH3:13])[CH2:6][C:7]([OH:9])=[O:8])(=[O:3])[NH2:2]

Participants

3

Reactant 1

HCID 24885501HCID 24885501, compound

Product 1

HCID 11084586(R)-3-(Carbamoylmethyl)-5-methylhexanoic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A flask is equipped with a magnetic stirrer and is charged with 3N HCl (100 ml) and (R)-methyl 3-(carbamoylmethyl)-5-methylhexanoate (20 g). The mixture is stirred for 1-10 hours at a temperature of 20° C. to 25° C., followed by quenching with 47% NaOH to pH 3. The resulting slurry is filtered, washed with water, and dried to obtain a white solid of (R)-3-(carbamoylmethyl)-5-methylhexanoic acid.

Workup

  1. customA flask is equipped with a magnetic stirrer
  2. customby quenching with 47% NaOH to pH 3
  3. filtrationThe resulting slurry is filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-0c4f0757e2c84607ae17cb43c0d89876
Source dataset
uspto-grants-2008_12
Patent number
US07462738B2

Reaction notes

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