反应详情

温度

0 °C

The compound obtained in Step B (3.73 mmol) is dissolved in 100 ml of a mixture of water and ethyl acetate (50/50). Potassium carbonate (11.2 mmol) is added and the reaction mixture is cooled to 0° C. Using an ice bath. Propanol chloride (4.6 mmol) is added dropwise and the mixture is stirred for 15 minutes in the cold state. When the reaction is complete, the organic phase is washed with hydrochloric acid solution (1M), washed with water, dried and evaporated under reduced pressure. The solution obtained is recrystallized from acetonitrile to yield the title product in the form of a white solid.

1. washthe organic phase is washed with hydrochloric acid solution (1M)
2. washwashed with water
3. customdried
4. customevaporated under reduced pressure
5. customThe solution obtained
6. customis recrystallized from acetonitrile