Benzonitrile, 4-bromo- → 4-Cyano-4'-(Trifluoromethyl)biphenyl

HRID 2374752Notes

Reaction equation

HRID 2374752 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:16]=[CH:15][C:12]([CH:13]=O)=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.FC(F)(F)C1C=CC(B(O)O)=CC=1.BrC1C=CC(C#[N:38])=CC=1>>[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:16]=[CH:15][C:12]([C:13]#[N:38])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 12162Benzonitrile, 4-bromo-HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 27827124'-(Trifluoromethyl)-4-biphenylcarbaldehyde

Product 1

HCID 43684634-Cyano-4'-(Trifluoromethyl)biphenyl

Procedure

Prepared by the method of intermediate D2 using 4-trifluoromethylbenzeneboronic acid and 4-bromobenzonitrile. 1H-NMR (DMSO) δ 7.99-7.94 (6H, m) 7.86 (2H, d); MS(APCI+) found (M+1)=248, C14H8NF3requires 247.

Sources & evidence

ORD record
ord-5dfd95fae1624e0091146fb2daeab8ac
Source dataset
uspto-grants-2008_12
Patent number
US07462620B2

Reaction notes

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