反应详情

In a similar manner as described for Intermediate 18, 6-(1-aminoethyl)-N-(3,4,5-trimethoxyphenyl)-1,2,4-triazin-3-amine (Intermediate 9) (0.17 g, 0.56 mmol), 3-(methoxycarbonyl)benzoic acid (0.18 g, 0.62 mmol), O-(7-azabenzotriazol-1-yl-N,N,N′N′-tetramethyluronium hexafluorophospahte (0.24 g, 0.62 mmol) and triethylamine (0.17 mL, 1.2 mmol) in N,N-dimethylformamide (5 mL) gave methyl 3-{[(1-{3-[(3,4,5-trimethoxyphenyl)amino]-1,2,4-triazin-6-yl}ethyl)amino]carbonyl}benzoate (0.26 g) as a white solid. MS m/z 468 (M+1).