反应详情

In a similar manner as described for Intermediate 10, 6-(1-aminoethyl)-N-(3,4,5-trimethoxyphenyl)-1,2,4-triazin-3-amine (Intermediate 9) (295 mg, 0.97 mmol), 4-(trifluoromethyl)benzoyl chloride (0.16 mL, 1.08 mmol), and triethylamine (0.168 mL, 1.20 mmol) in tetrahydrofuran (4 mL) gave 4-(trifluoromethyl)-N-(1-{3-[(3,4,5-trimethoxyphenyl)amino]-1,2,4-triazin-6-yl}ethyl)benzamide (284 mg, 59%) as a yellow solid. MS m/z 477 (M+1).