Hydrochloric Acid → HCID 136401929, compound

HRID 2375107Notes

Reaction equation

HRID 2375107 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C@@H:9]([NH:27]C(=O)OC(C)(C)C)[C:10](=[O:26])[NH:11][C:12]2[CH:13]=[C:14]3[C:24](=[O:25])[NH:23][N:22]=[CH:21][C:16]4=[CH:17][NH:18][C:19]([CH:20]=2)=[C:15]34)=[CH:4][CH:3]=1.[ClH:35]>O1CCOCC1>[ClH:35].[NH2:27][C@H:9]([CH2:8][C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=1)[C:10]([NH:11][C:12]1[CH:13]=[C:14]2[C:24](=[O:25])[NH:23][N:22]=[CH:21][C:16]3=[CH:17][NH:18][C:19]([CH:20]=1)=[C:15]23)=[O:26]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 136181655HCID 136181655, compound

Product 1

HCID 136401929HCID 136401929, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Preparation of example 178 from the title compound of Example 155 (90 mg, 0.194 mmol) and 4M HCl in dioxane (10 mL) was carried out analogously to Example 91. Isolation, also in an analogous manner afforded the title compound (56 mg, 0.140 mmol) as an orange/yellow powder in 72% yield.

Sources & evidence

ORD record
ord-bbac70355dfd473289f943ac8bbd442d
Source dataset
uspto-grants-2008_12
Patent number
US07462713B2

Reaction notes

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