反应详情

To a solution of 1-bromo-2-butanone (10.3 g, 57.98 mmol) in EtOH (200 mL) were added 2-cyanothioacetamide (5.8 g, 57.98 mmol) and triethylamine (1.59 mL, 11.6 mmol) and the solution was stirred under reflux for 1 h. After cooling down to r.t., the solvent was removed. The orange solid obtained was washed with AcOEt then cyclohexane, and recrystallized from EtOH to afford 7.2 g of the title compound as orange needles (Y=81%).

1. temperatureunder reflux for 1 h
2. customthe solvent was removed
3. customThe orange solid obtained
4. washwas washed with AcOEt
5. customcyclohexane, and recrystallized from EtOH