Trifluoroacetic acid → HCID 69311189, compound

HRID 2375316Notes

Reaction equation

HRID 2375316 reaction equation
[C:1]([C:3](=[C:25]1[NH:29][C:28]([CH2:30][CH3:31])=[CH:27][S:26]1)[C:4]1[CH:9]=[CH:8][N:7]=[C:6]([NH:10][CH:11]2[CH2:16][CH2:15][N:14](NC(OC(C)(C)C)=O)[CH2:13][CH2:12]2)[N:5]=1)#[N:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH:14]1[CH2:13][CH2:12][CH:11]([NH:10][C:6]2[N:5]=[C:4]([C:3](=[C:25]3[NH:29][C:28]([CH2:30][CH3:31])=[CH:27][S:26]3)[C:1]#[N:2])[CH:9]=[CH:8][N:7]=2)[CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69310039HCID 69310039, compound

Product 1

HCID 69311189HCID 69311189, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The Boc protected tert-butyl 4-({4-[cyano(4-ethyl-1,3-thiazol-2(3H)-ylidene)methyl]pyrimidin-2-yl}amino)piperidine-1-carbamate was treated with a solution of 20% TFA in DCM overnight at rt, affording the title compound as a diTFA salt after evaporation of the solvent (52.5%).

Sources & evidence

ORD record
ord-2cdeda945a4b4f8a9a5935a7fcff6a9c
Source dataset
uspto-grants-2008_12
Patent number
US07465736B2

Reaction notes

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