Potassium Carbonate → 1-Bromo-2-(difluoromethoxy)-4-fluorobenzene

HRID 2375767Notes

Reaction equation

HRID 2375767 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[OH:9].Br[C:11]([F:18])([F:17])C(OCC)=O.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[F:17][CH:11]([F:18])[O:9][C:3]1[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=1[Br:1]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 69585Ethyl bromodifluoroacetateHCID 27246002-Bromo-5-fluorophenol

Product 1

HCID 451587111-Bromo-2-(difluoromethoxy)-4-fluorobenzene

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

This compound is obtained in the form of an oil (unpurified) by refluxing a mixture of 2-bromo-5-fluorophenol and ethyl bromodifluoroacetate in acetone overnight in the presence of potassium carbonate.

Workup

  1. customThis compound is obtained in the form of an oil (unpurified)
  2. temperatureby refluxing

Sources & evidence

ORD record
ord-dd8014e211a443e6a4313b3292f729a4
Source dataset
uspto-grants-2008_12
Patent number
US07465811B2

Reaction notes

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