反应详情

A mixture of 5-bromopyrimidin-2(1H)-one (3 g), methyliodide (1.1 mL) and K2CO3 (2.4 g) in N,N-dimethylformamide (60 mL) is stirred for 5 hours at room temperature. The mixture is filtered and the mother liquor is concentrated. The residue is partitioned between water and dichloromethane. The organic phase is washed with brine, dried (MgSO4) and concentrated to give the title compound. Yield: 385 mg; LC (method 9): tR=0.25 min; Mass spectrum (ESI+): m/z=189 [M+H]+.

1. filtrationThe mixture is filtered
2. concentrationthe mother liquor is concentrated
3. customThe residue is partitioned between water and dichloromethane
4. washThe organic phase is washed with brine
5. dry with materialdried (MgSO4)
6. concentrationconcentrated