1-Benzyl-4-piperidone → HCID 21559974, compound

HRID 2376641Notes

Reaction equation

HRID 2376641 reaction equation
[Mg].Br[C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][CH:4]=1.[CH2:13]([N:20]1[CH2:25][CH2:24][C:23](=[O:26])[CH2:22][CH2:21]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C1COCC1>[CH2:13]([N:20]1[CH2:25][CH2:24][C:23]([C:3]2[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][CH:4]=2)([OH:26])[CH2:22][CH2:21]1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

5

Reactant 3

HCID 192201-Benzyl-4-piperidoneHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-HCID 5462224Magnesium

Product 1

HCID 21559974HCID 21559974, compoundYield 41.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent3×

Procedure

This compound is prepared by the procedure described in step A of preparation 1.7, from 1.55 g of magnesium in 25 ml of THF, a solution of 14.25 g of 1-bromo-4-(trifluoromethyl)benzene in 15 ml of THF and a solution of 10 g of 1-benzyl-4-piperidinone in 30 ml of THF. This gives 7.3 g of the expected product.

Workup

  1. customThis compound is prepared by the procedure

Sources & evidence

ORD record
ord-692848b6bb9c41ad9b5ad063ad63856f
Source dataset
uspto-grants-2008_12
Patent number
US07468368B2

Reaction notes

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