反应详情

温度

100 °C

A mixture of diethyl(4-acetyl-2-nitrophenyl)malonate and diethyl malonate (54.1 g) prepared by step a) was dissolved in 4M HCl (800 mL)/dioxane (800 mL), and the solution was stirred at 100° C. for 8 hours. After cooling, dioxane was removed in vacuo, and the aqueous layer was extracted with chloroform (200 mL×1, 100 mL×2). The organic layers were combined, dried over magnesium sulfate, filtered, and the solvent was removed in vacuo to give the object compound (23.1 g, quantitatively) as a brown solid.

1. temperatureAfter cooling
2. customdioxane was removed in vacuo
3. extractionthe aqueous layer was extracted with chloroform (200 mL×1, 100 mL×2)
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered
6. customthe solvent was removed in vacuo
7. customto give the object compound (23.1 g