Hydrochloric Acid → HCID 69145081, compound

HRID 2376691Notes

Reaction equation

HRID 2376691 reaction equation
CC(O[C:6](=O)[N:7]([CH2:9][CH2:10][NH:11][C:12]1[CH:21]=[N:20][C:19]2[C:14](=[CH:15][C:16]([F:23])=[C:17]([F:22])[CH:18]=2)[N:13]=1)C)(C)C.[ClH:25]>CO.O1CCOCC1>[ClH:25].[ClH:25].[F:22][C:17]1[CH:18]=[C:19]2[C:14](=[CH:15][C:16]=1[F:23])[N:13]=[C:12]([NH:11][CH2:10][CH2:9][NH:7][CH3:6])[CH:21]=[N:20]2

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 69147959HCID 69147959, compound

Product 1

HCID 69145081HCID 69145081, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

An ice-cooled solution of [2-(6,7-difluoro-quinoxalin-2-ylamino)-ethyl]-methyl-carbamic acid dimethyl-ethyl ester, D1 (500 mg, 1.48 mmol) in methanol (20 ml) was treated with HCl in dioxane (4M solution, 4 ml). After stirring under argon at room temperature for 4 h the volatiles were removed in vacuo and the residue was triturated with diethyl ether to afford the title compound as a beige powder (100%).

Workup

  1. customwere removed in vacuo
  2. customthe residue was triturated with diethyl ether

Sources & evidence

ORD record
ord-0029317dab264e77a22081b2841f838b
Source dataset
uspto-grants-2008_12
Patent number
US07468367B2

Reaction notes

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