Potassium Carbonate → HCID 69144507, compound

HRID 2376694Notes

Reaction equation

[CH3:1][C:2]([O:5][C:6](=[O:12])[N:7]([CH2:9][CH2:10][NH2:11])[CH3:8])([CH3:4])[CH3:3].Cl[C:14]1[N:19]=[CH:18][C:17]([Br:20])=[CH:16][N:15]=1.C(N(CC)C(C)C)(C)C.C([O-])([O-])=O.[K+].[K+]>>[CH3:4][C:2]([O:5][C:6](=[O:12])[N:7]([CH2:9][CH2:10][NH:11][C:14]1[N:19]=[CH:18][C:17]([Br:20])=[CH:16][N:15]=1)[CH3:8])([CH3:1])[CH3:3]

Participants

Reactant 4

HCID 11430Potassium Carbonate

HCID 81531Diisopropylethylamine

HCID 6066655-Bromo-2-chloropyrimidine

HCID 2756424N-Boc-N-methylethylenediamine

Product 1

HCID 69144507HCID 69144507, compoundYield 73%

Procedure

The title compound (2.40 g, 73%) was prepared from (2-amino-ethyl)-methyl-carbamic acid dimethyl-ethyl ester (1.74 g, 10 mmol), 2-chloro-5-bromo-pyrimidine (1.93 g, 10 mmol), N,N-diisopropylethylamine (3.87 g, 30 mmol) and K2CO3 (2.76 g, 20 mmol) according to the procedure described for Description 1.

Sources & evidence

ORD record: ord-b4d6718f6b964fdba8be15c006dde288
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07468367B2

Reaction notes

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