反应详情

To a solution of Example 318 (980 mg, 3.16 mmol) in dichloromethane was added 1-methylpiperazine (0.83 mL, 7.5 mmol) and acetic acid (0.43 mL, 7.5 mmol) and the mixture was stirred at room temperature overnight. To this mixture was added sodium triacetoxyborohydride (1.0 g, 4.7 mmol) followed by methanol (5 mL) and stirring at room temperature was continued for about 2 days. The mixture was evaporated to dryness and the residue was purified by flash chromatography on silica gel using dichloromethane/methanol (9:1)+1% ammonium hydroxide as eluent to provide Example 607. MS (ESI): m/z 395 (M+H)+.

1. stirringstirring at room temperature
2. waitwas continued for about 2 days
3. customThe mixture was evaporated to dryness
4. customthe residue was purified by flash chromatography on silica gel
5. customto provide Example 607