Dimethylformamide → HCID 69203755, compound

HRID 2377289Notes

Reaction equation

HRID 2377289 reaction equation
[CH3:1][C:2]1[CH:10]=[C:9]([CH2:11][N:12]2[CH:16]=[C:15](C)[N:14]=[CH:13]2)[CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:18].[CH3:19]C1N=CNC=1.CN1CCNCC1.CN(C=O)C>CCO>[CH3:1][C:2]1[CH:10]=[C:9]([CH2:11][N:12]2[C:16]([CH3:19])=[CH:15][N:14]=[CH:13]2)[CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:18]

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 531671-MethylpiperazineHCID 69202595HCID 69202595, compoundHCID 178418800HCID 178418800, compound

Product 1

HCID 69203755HCID 69203755, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of Example 922A and Example 922B was obtained by substituting Example 917G for Example 54, 4-methylimidazole for N-methypiperazine, and DMF for EtOH in Example 56. The isomers were separated by flash chromatography.

Workup

  1. customThe isomers were separated by flash chromatography

Sources & evidence

ORD record
ord-3d546d813bb74d38951ce2b8e94a3ff0
Source dataset
uspto-grants-2008_12
Patent number
US07468371B2

Reaction notes

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