4-Aminopyridine → HCID 86602683, compound

HRID 2377293Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[C:8]([C:11]1C=CC=C2[C:12]=1[CH2:13][CH2:14]C2=O)(O)=[O:9].Cl.CNC>>[N:5]1[CH:6]=[CH:7][C:2]([NH:1][C:8](=[O:9])[CH2:11][CH2:12][C:13]#[CH:14])=[CH:3][CH:4]=1

Participants

Reactant 3

HCID 17274-Aminopyridine

HCID 10473Dimethylamine, hydrochloride

HCID 125422061-Oxo-indan-4-carboxylic acid

Product 1

HCID 86602683HCID 86602683, compound

Procedure

The desired product was prepared by substituting 4-pentynoic acid and 4-aminopyridine for 4-carboxy-1-indanone and dimethylamine hydrochloride, respectively, in Example 40. MS (APCI(+)) m/e 175.1 (M+H)+.

Sources & evidence

ORD record: ord-32b99bc3ceb64e569ee7588a0dd139ad
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07468371B2

Reaction notes

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