反应详情

A mixture of 400 mg of ethyl 6-(2-ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydro-pyridazine-4-carboxylate, 2 ml of THF, 2 ml of water, 2 ml of methanol and 100 mg of lithium hydroxide is stirred at room temperature for 1 hour, and the volatile constituents are removed in vacuo. A pH of 4 is adjusted by dropwise addition of 2N hydrochloric acid, and the precipitate which has formed is filtered off with suction, stirred with 10 ml of isopropanol and filtered off with suction and dried.

1. customthe volatile constituents are removed in vacuo
2. additionA pH of 4 is adjusted by dropwise addition of 2N hydrochloric acid
3. customthe precipitate which has formed
4. filtrationis filtered off with suction
5. stirringstirred with 10 ml of isopropanol
6. filtrationfiltered off with suction
7. customdried